Nom i cognoms / Name and surname
Carole Amroune
Afiliació / Affiliation
ISGlobal
Programa de finançament europeu en que s’enmarca aquest projecte? / European funding programme in which this project is being carried out?
EU support (FP7, H2020, etc.) other than MSCA
Títol del projecte / Project title
EChiLiBRiST – Development and validation of a quantitative point-of-care test for the measurement of severity biomarkers to improve risk stratification of fever syndromes and enhance child survival
Número del projecte / Project number
101057114
Breu explicació del projecte / Brief explanation of your project
The EU-funded Project EChiLiBRiST will develop and trial a rapid test for the early recognition and management of febrile patients at risk ofsevere disease.
During the first 2 years, we will develop and validate a laboratory prototype, as well as develop a functional prototype to produce mini-series to test in the field. During the next 3 years, we will perform clinical trials in 3 different African countries to determine its performance in febrile children, in terms of appropriately supporting the decision of hospital admission compared to the standard of care triaging approaches. In addition, we will determine the effectiveness of L-citrulline supplementation (targeting endothelial activation) in improving long-term outcomes among children risk-stratified by our test. Finally, these trials will be accompanied by health impact and economic modelling of nation-wide introduction of the test, as well as feasibility and acceptance of the rapid triage strategy by healthcare providers and community.
Enllaç a la pàgina web del projecte / Link to your project website
Repte en que s’emmarca aquest projecte / Challenge within the framework of this project
Does not apply
