BLOC: Benchtop NMR for lab-on a-chip

Poster European Corner

Nom i cognoms / Name and surname

Irene Marco-Rius

Afiliació / Affiliation

Institute for Bioengineering of Catalonia (IBEC)

Programa de finançament europeu en que s’enmarca aquest projecte? / European funding programme in which this project is being carried out?

EU support (FP7, H2020, etc.) other than MSCA

Títol del projecte / Project title

BLOC: Benchtop NMR for lab-on a-chip

Número del projecte / Project number

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under No. 863037.

Breu explicació del projecte / Brief explanation of your project

BLOC project is developing a benchtop NMR spectrometer based on magnetic resonance spectroscopy and imaging using dynamic nuclear polarisation (DNP-MR). The integration of this technology with tissue engineering systems will be applied to monitor disease and evaluate responses to different stimulus. As a proof-of-concept, researchers will fabricate a biomimetic model composed of liver spheroids and pancreatic islets and develop the necessary DNP-MR hardware and software to study metabolic diseases.
The benchtop device will accommodate microfluidic platforms containing 3D in vitro models and enable the study of their cellular metabolism in real-time, in situ and non-destructively by hyperpolarization-enhanced MRS. This technology will be applied to monitor disease and evaluate responses of bioengineered tissues to different stimuli.
The technology derived from this project will have a direct impact in the society and the public opinion since it will allow a significant reduction on the use of animals for experimentation purposes, minimizing ethical issues related with this topic. Moreover, the use of human engineered tissues will bring pre-clinical experiments more accurate and efficient, facilitating the extrapolation of results to humans.
The idea is to create a standardized and small device which can be easily installed in any laboratory. Besides being used in the biomedical field, the equipment developed in this project will be an easy-to-use and low-cost system with potential applications in other areas, as environmental control and chemical industry.

Enllaç a la pàgina web del projecte / Link to your project website

Repte en que s’emmarca aquest projecte / Challenge within the framework of this project

Does not apply



Amb el suport de:

Amb el finançament de:

Aquest projecte està cofinançat pel programa de recerca i innovació Horizon Europe de la Unió Europea sota el projecte NitRecerCat (101061189).

This project is co-funded by the European Union’s research and innovation programme Horizon Europe, under the project NitRecercat (101061189).