Nom i cognoms / Name and surname
Mariona Gispert-Llaurado, Irina Gheorghita, Lara Vehovec, Natàlia Ferré, Noelia Ramírez, Jeannie Horak, Hans Demmelmair, Bernadeta Patro-Golab, Veit Grote, Berthold Koletzko, Gabi Kastenmüller, Klaus Kratochwill, Elvira Verduci, Dariusz Gruszfeld, Joaquin Escribano, Veronica Luque.
Afiliació / Affiliation
Paediatrics, Nutrition and Development Research Unit, IRBCatSud, Universitat Rovira i Virgili, Reus, Spain.
Programa de finançament europeu en que s’enmarca aquest projecte? / European funding programme in which this project is being carried out?
Other (EU support, FP7, H2020, etc.)
Títol del projecte / Project title
Biomarker signatures of diet, physical activity and sleep in children and youth
Número del projecte / Project number
This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the ERA-NET Cofund action Number 727565, JPI-HDHL-INTIMIC 2021; Instituto de Salud Carlos III (ISCIII) and Next Generation EU funds for actions of the Recovery, Transformation and Resilience Plan (PRTR) under grant agreement AC21_2/00010 (IISPV); Bundesministerium für Bildung und Forschung (BMBF) under grant agreements 01EA2203A (LMU) and 01EA2203B (HMGU); and Österreichische Forschungsförderungsgesellschaft mbH (FFG) and the MissionERA program under grant agreement FO999890543 (MUW)
Breu explicació del projecte / Brief explanation of your project
The BIOMARKID project aims to identify objective biomarkers of diet and lifestyle in children and adolescents using metabolomic and proteomic approaches. These biomarkers could complement traditional dietary assessment methods, which often rely on self-reported information and may be affected by recall errors and misreporting.
As part of the BIOMARKID project, we conducted a systematic review to investigate the association between dietary intake and the metabolome in children and adolescents. Eight studies, including 5,992 participants from 12 countries, were included. Metabolites were measured in blood and/or urine samples using targeted and untargeted metabolomic approaches.
Several metabolites were consistently associated with specific dietary patterns and food groups. Higher adherence to a Mediterranean diet and greater fruit and vegetable intake were associated with higher levels of metabolites such as hippurate, trigonelline/N-methylnicotinic acid, and proline betaine. In contrast, higher consumption of ultra-processed foods was associated with lower levels of branched-chain amino acids (BCAAs), tyrosine, hippurate, and trigonelline/N-methylnicotinic acid. Vegan diets were also associated with lower levels of BCAAs, tyrosine, taurine, and DHA, while fish intake was associated with higher levels of specific phosphatidylcholines.
Overall, these findings suggest that metabolomics can help identify objective biomarkers reflecting dietary intake in children and adolescents. However, further studies are needed to validate these metabolites before they can be used as reliable dietary biomarkers in pediatric populations.
Enllaç a la pàgina web del projecte / Link to your project website
